Advanced Protein Characterization Facility

Argonne, Illinois / United States of America

The Advanced Protein Characterization Facility (APCF) for Argonne National Laboratory (ANL) in Argonne, Illinois, United States encompasses a multidisciplinary science and engineering research center. This 55,000 gsf world-class facility is a catalyst for  advancements in biological research as it provides researchers with the most advanced technology and laboratory space for protein science experiments in Illinois and nationwide. The design of the APCF is resolved as a flexible, modern space that strikes a balance between internal functionality and external presence. APCF is organized into two rectangles that are joined together by a central spine, each containing separate programmatic elements: offices and laboratories, as well as touchdown collaboration spaces.

Designing and constructing an extension to the Advanced Protein Source (APS) building was a significant challenge. With just a two hour window per week when the APS could be offline, precise coordination was required to integrate building systems, such as the magnet cooling water, in order to optimize operational efficiencies and achieve sustainability goals.

The simplicity of the design of the APCF provides a backdrop that puts the leading edge biological research on display and solidifies ANL as the most innovative research facility in the nation.

Architect of Record



Argonne National Laboratory

General Contractor

Clark Construction Group, LLC


  • Thornton Tomasetti
  • Affiliated Engineers Inc. (AEI)
  • TERRA Engineering